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EP2039754A1 - Bioreactor, cell culture method, and .

EP2039754A1 EP08014470A EP08014470A EP2039754A1 EP 2039754 A1 EP2039754 A1 EP 2039754A1 EP 08014470 A EP08014470 A EP 08014470A EP 08014470 A EP08014470 A EP 08014470A EP 2039754 A1 EP2039754 A1 EP 2039754A1 Authority EP European Patent Office Prior art keywords culture tank impellers impeller bioreactor plurality Prior art date 2007-09-21 Legal status .

Industrial Microbiology Btech. 6 Sem | Chemical Reactor .

Industrial Microbiology. BTech. 6th Sem PPT-1 Introduction to industrial biotechnology Industrial microorganisms Fermentor / Bioreactor Design. Dr. Arun Kumar Pradhan Assistant Professor CBT, SOA University Industrial Microbiology The Scope:. 1. This course seeks to introduce students to those aspects of applied microbiology which they are likely to encounter in the Fermentation/Medicare sector.

Bioreactors for plant cell cultures

Apr 04, 2014 · Types of Bio-reactors Used in Plant Cultures • Mechanically agitated bioreactors • Pneumatically driven bioreactors • Hydro dynamically driven disposable bioreactors • Non-Agitated bioreactor 4 5. Mechanically agitated bioreactors 5 Stirred tank reactors Rotary Drum bioreactors 6.

PPT – Heat Transfer in Fermentation PowerPoint .

rotary drum drier, vacuum tray drier, or freeze-drier. 27 Chapter X. Bioreactor; 28 Bioreactor configurations Stirred tank bioreactor Similar to CSTR this requires a relatively high input of energy per unit volume. Baffles are used to reduce vortexing. A wide variety of impeller sizes and shapes is available to produce different flow

Large Sale Cultivation of Plant Cell and Tissue Culture in .

Dec 18, 2009 · The bioreactors used for various plant cell cultures are classified as mechanically agitated, pneumatically driven, disposable and non-agitated (Fig. 1). The most common bioreactor is the stirred .

Full text of "Biorector 03"

BIOREACTOR DESIGNS The major types of bioreactors used in industry include: Stirred tank reactors In these reactors, mechanical stirrers (using impellers) are used to mix the reactor to distribute heat and materials (such as oxygen and substrates) Bubble column reactors These are tall reactors which use air alone to mix the contents Bioreactor .

TOPIC 5 _ Types of Bioreactor | Chemical Reactor .

Bioreactor Configurations - 1. Stirred tank Mixing method: Mechanical agitation Baffles are usually used to reduce vortexing Applications: free and immobilized enzyme reactions High shear forces may damage cells Require high energy input Stirred Tank Bioreactors (STB) STB is the choice for more than 70% of industrial work. though it is not the .

Bioreactors, Stirred Tank for Culture of Plant Cells .

Bioreactors, Stirred Tank for Culture of Plant Cells. Pauline M. Doran. Monash University, School of Biological Sciences and Department of Chemical Engineering, Victoria, Australia, VIC 3800. Search for more papers by this author. Pauline M. Doran.

Advances in cell culture: anchorage dependence .

1. Introduction. The development of animal cell technology began with the initiation of the production of viruses for vaccine purposes, starting with the cultivation of primary cells (monkey kidney cells and chicken embryo fibroblasts), followed by the development of diploid cell cultures (from humans, such as human fetal lung fibroblasts (WI-38, MRC-5) or from monkeys, such as DBC-FRhL-2 .

Review of Measuring Methods and Results in Nonviscous Gas .

Application of a two-dimensional disposable rocking bioreactor to bacterial cultivation for recombinant protein production. . Bioreactors, Stirred Tank for Culture of Plant Cells. 2010, . Oxygen transfer and mixing in mechanically agitated airlift bioreactors. Biochemical Engineering Journal 2002, 10 (2), 143-153. DOI: 10.1016/S1369-703X .

Bioreactor technology for clonal propagation of plants and .

Mar 30, 2015 · Plant cell culture in bioreactors is an enabling tool for large scale production of clonal elite plants in agriculture, horticulture, forestry, pharmaceutical sectors, and for biofuel production. Advantages of bioreactors for plant cell culture have resulted in various types of bioreactors differing in design, operating technologies, instrumentations, and construction of culture vessels.

Technological problems in cultivation of plant cells at .

Using Cudrania tricuspidata cells as model plant cells which have high sensitivity to hydrodynamic stress, technology problems in the cultivation of the plant cells at high density were investigated. Using "shake" flasks on a reciprocal shaker and Erlenmeyer flasks on a rotary shaker and with a high supply of oxygen on order to obtain high cell densities in shaken cultures, particles .

Full text of "Biorector 03"

BIOREACTOR DESIGNS The major types of bioreactors used in industry include: Stirred tank reactors In these reactors, mechanical stirrers (using impellers) are used to mix the reactor to distribute heat and materials (such as oxygen and substrates) Bubble column reactors These are tall reactors which use air alone to mix the contents Bioreactor .

Slide 1

Stirred Tank Bioreactors (STB) Stirred tank reactor is the choice for many (more than 70%) though it is not the best. STB's have the following functions: homogenization, suspension of solids, dispersion of gas liquidmixtures . aeration of liquid . heat exchange

Bioreactors - Encyclopedia of Life Support Systems

Mechanically mixed bioreactors use different impellers, motor driven from the top or the bottom, or some other means, for e.g. vibration of the impeller or the whole reactor. Basical problems in this type of bioreactors are mechanical seals, the motor drive and the type of impeller. The most used types of impellers in mechanically mixed bioreactor

EP2039754A1 - Bioreactor, cell culture method, and .

EP2039754A1 EP08014470A EP08014470A EP2039754A1 EP 2039754 A1 EP2039754 A1 EP 2039754A1 EP 08014470 A EP08014470 A EP 08014470A EP 08014470 A EP08014470 A EP 08014470A EP 2039754 A1 EP2039754 A1 EP 2039754A1 Authority EP European Patent Office Prior art keywords culture tank impellers impeller bioreactor plurality Prior art date 2007-09-21 Legal status .

Bioreactors : design, operation and novel applications .

You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them.

Types Of Fermenters - Bioprocessing

Stirred tank reactor's have the following functions: homogenization, suspension of solids, dispersion of gas-liquid mixtures, aeration of liquid and heat exchange. The Stirred tank reactor is provided with a baffle and a rotating stirrer is attached either at the top or at the bottom of the bioreactor.

bioreactors bed packed reactor types

Bioreactors Types Top 3 Types of Bioreactors. Mechanically Agitated Bioreactors The mechanically agitated bioreactors are most commonly used for large scale culture of plant animal and microbial cells In this type of bioreactor the medium is agitated with the help of a mechanically driven impeller Various types of impellers are in use depending .

Fluid Dynamics of a Single-Use, Stirred-Tank Bioreactor .

Sep 23, 2015 · In a future publication, we will present results of studies on cell-culture performance and scalability of this bioreactor using a Chinese hamster ovary (CHO) cell line, comparing Allegro STR 200 performance with that of a 10-L glass, multiuse, stirred-tank bioreactor (2).

Types Of Fermenters - Bioprocessing

Stirred tank reactor's have the following functions: homogenization, suspension of solids, dispersion of gas-liquid mixtures, aeration of liquid and heat exchange. The Stirred tank reactor is provided with a baffle and a rotating stirrer is attached either at the top or at the bottom of the bioreactor.

Notice bibliographique Fermentation and biochemical .

Type(s) de contenu et mode(s) de consultation : Texte : électronique Titre(s) : Fermentation and biochemical engineering handbook [Texte électronique] : principles, process design, and equipment Édition : 3d edition / edited by Henry C. Vogel, Chapel Hill, WC and Celeste M. Todaro, Celes Tech Inc., Haddonfield, New Jersey Publication : Amsterdam : William Andrew, an imprint of Elsvier, 2014

Bioreactor Design and Bioprocess Controls for .

Jun 01, 2012 · As in all cell culture expansion, the bioreactor type for stem cell expansion largely depends on whether the cells are growing as single cells in suspension, in monolayers, or in cell aggregates. Large cell densities combined with large cell amounts can be achieved in membrane reactors, stirred reactors, rotary reactors, fixed-bed reactors, and .

Bioreactor technology for clonal propagation of plants and .

Fig.1 Different designs of stirred tank bioreactor; rotation of impeller in the bioreactor provides agitation to the liquid medium that helps to maintain homogeneity of nutrient and O 2 in the medium. (A) Schematic of a conventional stirred tank bioreactor (Jay et al.,1992). (B) Stirred tank bioreactor with plastic mesh for immobilization of hairy roots (Cardillo et al., 2010).

Stirred-Tank Bioreactors - an overview | ScienceDirect Topics

Shahryar Jafarinejad, in Petroleum Waste Treatment and Pollution Control, 2017. 6.4.3.1.4 Continuous Stirred Tank Bioreactor. The continuous stirred tank bioreactor (CSTB) is the other suspended growth process (Ishak et al., 2012) and is based on a conventional mixed-flow reactor (MFR) or continuous stirred tank reactor (CSTR).It requires air supply and the stirrer .

Large scale industrialized cell expansion: producing the .

Nov 05, 2015 · Also, microcarrier based expansion of BM MSC and adipose tissue-derived stem/stromal cell was established using a 1 L stirred-tank bioreactor to (1.1 ± 0.1) × 10 8 and (4.5 ± 0.2) × 10 7 cells respectively within 7 days of culture . Similarly, stirred tank bioreactor was used to expand mES cells on microcarriers using serum-free medium .

Secondary Metabolites Production in Bioreactors (7 .

Efforts to use air-lift type bioreactor were frustrated by the 'bubbling-up' of the cells and the subsequent adherence of the cells to the tank wall. These authors then adopted a rotary drum type tank which revolved slowly, thus washing cells from the wall (Fig. 28.8). This system has been scaled-up to 1000L without loss in shikonin production.

Bioreactor technology for clonal propagation of plants and .

Mar 30, 2015 · Plant cell culture in bioreactors is an enabling tool for large scale production of clonal elite plants in agriculture, horticulture, forestry, pharmaceutical sectors, and for biofuel production. Advantages of bioreactors for plant cell culture have resulted in various types of bioreactors differing in design, operating technologies, instrumentations, and construction of culture vessels.

1 ChallengesforBioreactorDesignandOperation

Bioreactors: Design . The main shortcoming of the stirred bioreactor, its mechanical agitation, is solved in other bioreactor designs. In the bubble column bioreactor, the . solid-phase tray reactor, (h) rotary drum bioreactor, (i) agitated-tank reactor with mov-able impeller, (j) continuous screw bioreactor, (k) hollow-fiber reactor, and .

Keeping up with Single-Use - ISPE Boston

Oct 07, 2015 · bioreactors Mid to Large‐Scale Cell Culture APPLICATION: Culture of mammalian, insect or plant cells in suspension (recently microbial fermenters to 500 L) CAPACITY:50 L – 2000 L VENDORS: GE, Sartorius, Thermo, Millipore, Pall NOTES: Stirred tank design based on bioprocess bag assembly provided as complete, gamma‐