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The five reactions on every organic chemist's wish list .

Adding even a single fluorine atom onto a molecule can increase its metabolic stability and lipophilicity. A reaction to quickly fix radioactive fluorine-18 onto molecules could also be a boon for medical positron-emission tomography.. But there's no straightforward way to replace a specific hydrogen atom with a fluorine once the molecular structure has been assembled, explains Astex's .

Scientists propose strategy for site-selective chiral drug .

Jun 26, 2020 · In chiral drug synthesis that uses bio-orthogonal chemistry within complex biological milieu, asymmetric transfer hydrogenation (ATH), which .

A novel strategy to achieve site-selective chiral drug .

Jun 26, 2020 · In chiral drug synthesis that uses bioorthogonal chemistry within complex biological milieu, asymmetric transfer hydrogenation (ATH), which .

Scientists use a Teflon pipe to make a cheap, simple .

Scientists use a Teflon pipe to make a cheap, simple reactor for silica particle synthesis Functional silica beads for biomedical imaging, drug delivery and other important applications could be .

DRUG SYNTHESIS – All About Drugs

GLENMARK SCIENTIST, NAVIMUMBAI, INDIADR ANTHONY MELVIN CRASTO Ph.D, Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT,1991, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, . Currently he is working with GLENMARK- GENERICS LTD, Research centre as Principal Scientist, Process .

Syrris - Automated Flow & Batch Chemistry Systems

Syrris is a world leader in flow chemistry, batch chemistry reactor systems, and chemical scale-up solutions. Syrris products are used in laboratories around the world for applications including process development, discovery chemistry, reaction calorimetry, crystallization, and process scale-up.

New technology enables fast protein synthesis | MIT News

May 28, 2020 · In their machine, chemicals are mixed using mechanical pumps and valves, and at every step of the overall synthesis they cycle through a heated reactor containing a resin bed. In the optimized protocol, forming each peptide bond takes on average 2.5 minutes, and peptides up to 25 amino acids long can be assembled in less than an hour.

Rhodium: Drug Chemistry Archive

The Synthesis of Nitrostyrenes by the Henry Reaction Synthesis of 4-Fluoro-2,5-Dimethoxyamphetamine (DOF) High-yielding synthesis of Amphetamines using a Horner-Wadsworth-Emmons Olefination

Chemical Synthesis - Creative Biolabs

Fighting Drug Resistance. Drug resistance has become a severe problem in recent years. Chemical modification strategy has been developed to make various analogs of existing drugs and provide new ways attacking drug-resistant pathogens. Creative Biolabs offers parallel synthesis service which prepares modules in separate and parallel reaction.

THE SYNTHESIS OF SULFA DRUGS - Mercer University

THE SYNTHESIS OF SULFA DRUGS Introduction In this experiment, you will use your organic chemistry expertise to synthesize a sulfa drug, then test its effectiveness in inhibiting bacterial growth. Time and availability of instruments permitting, you may also take an IR and a 1H NMR spectrum of your product. The following experiment has

Electrochemical reaction powers new drug discoveries

Jun 30, 2020 · Newly designed ligands for a catalytic reaction to synthesize drugs and useful compounds Jun 29, 2020 Scientists propose strategy for site-selective chiral drug synthesis in .

Small Pressure Vessels,Biodiesel,Hydrothermal Reaction .

Small Pressure Vessels,Biodiesel,Hydrothermal Reaction,Drug Synthesis,Ptfe,Chemical Reactor, Find Complete Details about Small Pressure Vessels,Biodiesel,Hydrothermal Reaction,Drug Synthesis,Ptfe,Chemical Reactor,High Quality Small Pressure Vessels,Horizontal Pressure Vessel,Small Pressure Hydrothermal Reaction from Reactors Supplier or Manufacturer-Xian Toption .

Expanding the Medicinal Chemist Toolbox: Comparing Seven .

diverse set of alkyl groups on "drug-like" aryl structures via parallel library synthesis. Each method showed substrates that it excelled at coupling compared with the other methods. When analyzing the reactions run across all of the methods, a reaction success rate of 50% was achieved. Whereas this is promising, there are still gaps in

Synthesis of paracetamol from p-aminophenol - Labmonk

BACKGROUND. Principle: The synthesis of the amide essentially just requires running the reaction under certain temperature conditions with an appropriate catalyst. Paracetamol is prepared from p- aminophenol by acetylating it with acetic anhydride in the presence of 3-4 drops of concentrated sulphuric acid as catalyst. 1 Aim: To prepare paracetamol from p-aminophenol.

Chemical synthesis | Britannica

Chemical synthesis, the construction of complex chemical compounds from simpler ones. It is the process by which many substances important to daily life are obtained. It is applied to all types of chemical compounds, but most syntheses are of organic molecules. Chemists synthesize chemical

Medicinal Chemistry, Drug synthesis methods and strategies .

Medicinal Chemistry, Drug synthesis methods and strategies, Innovation in organic asymmetry. Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions.

Green chemistry for chemical synthesis | PNAS

Sep 09, 2008 · Reactions. Reactions play the most fundamental role in synthesis. The ideology of Green Chemistry calls for the development of new chemical reactivities and reaction conditions that can potentially provide benefits for chemical syntheses in terms of resource and energy efficiency, product selectivity, operational simplicity, and health and environmental safety.

Peptide synthesis - continuous flow chemistry - Vapourtec

As of 2016 there are over 50 peptide drugs in the market (non-insulin derived) with approximately 170 in various stages of clinical development. 2 Total sales of peptide drugs in 2015 are estimated to be approximately 50 billion. 3 Currently, most commercial peptide synthesis is performed in sequential or multi-parallel reactors with scale .

Synthesis Reaction Description Plus Examples

May 10, 2019 · A synthesis reaction or direct combination reaction is a type of chemical reaction in which two or more simple substances combine to form a more complex product. The reactants may be elements or compounds, while the product is always a compound.

Self-triggered click reaction in an Alzheimer's disease .

Due to its high efficiency, fast kinetics, and mild reaction conditions, the Cu(i)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction has received special attention in many biochemical applications such as bioconjugation, 7–11 biosensing, 12–14 and drug synthesis. 15,16 Many kinds of Cu sources are efficient for CuAAC bioorthogonal .

Solved: Cyclohexenone Is A Useful Starting Material For Dr .

Cyclohexenone is a useful starting material for drug synthesis. For each reaction below, predict the major addition product for the reaction between an ?,?-unsaturated ketone and carbon nucleophile. Expert Answer (158 ratings) Previous question Next .

Drug synthesis

Drug synthesis Ulf Ellervik Organic Chemistry Lund University. 2 Lecturer: Martin Johansson 0708-678687 [email protected] . Claisen-Schmidt reaction* Clemmensen reduction Cope rearrangement Curtius rearrangement Dieckmann condensation* Diels-Alder reaction.

An overview of the synthetic routes to the best selling .

An alternative process is based on the availability of 3-picoline (1.15) which is generated as a major side product in the synthesis of pyridine prepared from formaldehyde, acetaldehyde and ammonia in a gas phase reaction .The 3-picoline can be readily oxidised via another gas-phase protocol using a fixed-bed reactor charged with vanadium pentoxide on high surface titanium dioxide (5–50 wt .

Continuous Flow Reactors - eckertliottagroup

the laboratory. The product synthesis is a fully developed synthetic pathway to the product and is used in pilot-plants. The scaled out product synthesis is used in industry to meet high throughput demands. Reactor Microstructure The Corning continuous flow reactor is an assembly of microstructures (161mm x

Clandestine Drug Synthesis - []

The most frequently encountered synthesis of these compounds (Fig 13) is by N-acylation of anthranilic acid followed by reaction with a substituted aniline under dehydrating conditions (PCl 3, POCl 3, polyphosphoric acid or simply heating the mixture in a microwave). 3 The analogs that have been identified in the illicit drug market are shown .

Review Chemical reaction engineering, process design and .

Results relative to reaction paths unrealizable in batch mode are also presented [17]. Finally, flow chemistry has been very effectively described as a way to expand the process window [11,12]. 2.1. Fine chemicals and drugs synthesis The preparation of drugs and pharmaceutical active ingredients is usually carried out in batch or semi-

Synthesis Reaction Description Plus Examples

May 10, 2019 · A synthesis reaction or direct combination reaction is a type of chemical reaction in which two or more simple substances combine to form a more complex product. The reactants may be elements or compounds, while the product is always a compound.

Continuous flow chemistry in the pharmaceutical industry .

Sep 27, 2018 · The future of continuous flow chemistry in the pharmaceutical industry. With the extremely challenging process of bringing a new medicine to market costing an average of 2.6B and taking up to 12 years, it is vital that pharmaceutical companies optimize the drug discovery and development process, to maximize the lifetime of the medicine before patents expire.

Remdesivir - Wikipedia

Remdesivir, sold under the brand name Veklury, is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein. Remdesivir is being tested as a treatment for COVID‑19, and has been authorized for emergency use in the US, India, Singapore, and approved for use in Japan, the European Union, and Australia for .

Lysergic Acid Diethylamide (LSD) Syntheses

LSD Synthesis. As with the rest of this book, I will deal only with the synthetic manufacture of drugs (LSD included). If you want to grow the ergot alkaloids that begin the total synthesis of LSD, then you will have to go to the Merck Index and look up the references to the operation.